Anti-phospho-CENP-A (Ser7) Antibody, clone NL41, rabbit monoclonal

Descrição detalhada : CENP-A is a variant version of histone H3 found only at centromeres. It is phosphorylated at serine 7 during mitosis., Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of alpha-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
Armazenamento : -20°C
Embalagem : 1X1EA