Anti-phospho-PKR (pThr451) antibody produced in rabbit

Descrição detalhada : Protein kinase regulated by RNA (PKR) is an interferon-inducible ser/thr protein kinase, activated by stress signals and double-stranded RNA (dsRNA). In response to viral infection, PKR is activated by dsRNA-mediated dimerization and autophosphorylation. ?-subunit of protein synthesis initiation factor 2 (eIF-2?) is well-studied substrate of PKR. Activation by PKR leads to phosphorylation on Ser51 that result in inhibition of translation. Human PKR contains at least 15 autophosphorylation sites. But phosphorylation on threonine 446 and 451 in the PKR activation loop is required in vivo and in vitro for high-level kinase activity. PKR is implicated in signalling pathways that involve NF-?B, p38, and IRF-3 and is the key effector in IFN-induced anti-viral responses, apoptosis and protein synthesis. Anti-Phospho-PKR [pThr451] specifically recognizes PKR phosphorylated on threonine 451 (65-68 kDa). The antibody detects human and mouse PKR [pThr451].
Sinónimos : Anti-phospho-Interferon-Inducible Double-Stranded RNA-Dependent Protein (pThr451)
Armazenamento : -20C
Embalagem : 1X1VL