Anti-PQBP1 Antibody

Descrição detalhada : Polyglutamine-binding protein 1 (PQBP1), also known as PQBP-1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1, is encoded by the gene name PQBP1/ NPW38/ JM26. Recent studies have implied that PQBP1 may suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. PQBP1 has also been shown to activate transcription directly, or via association with the transcription machinery. PQBP1 might be involved in ATXN1 mutant-induced cell death. PQBP1 has been shown to interact with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. In addition, PQBP1 interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. PQBP1 forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. PQBP1 is widely expressed with high levels in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. Mutations in PQBP1 have been associated with Renpenning syndrome 1 (RENS1), an X-linked mental retardation syndrome characterized by mental retardation, microcephaly, short stature, and small testes.
Sinónimos : Polyglutamine-binding protein 1, PQBP-1, PQBP 1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA