Anti-ROR gamma T Antibody, clone 6F3.1

Descrição detalhada : Retinoid-related orphan receptor-gamma t (RORgammaT) is one of two RORgamma isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORgammaT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORgammaT is a requirement for TH17 cell differentiation. Inhibition of RORgammaT is induced by TGF-beta's interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.
Sinónimos : Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA