Anti-SQSTM1 Antibody, clone 20F1.1

Descrição detalhada : Ubiquitin-binding protein p62, also known as Sequestosome-1 (SQSTM1), is a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kappaB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kappaB in response to upstream signals. Defects in p62/SQSTM1 are a cause of Paget disease of bone (PDB), a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts
Sinónimos : Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA