Anti-STAT3 Antibody, clone 18F7.1

Descrição detalhada : STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway - a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage.
Sinónimos : Acute-phase response factor DNA-binding protein APRF signal transducer and activator of transcription 3 signal transducer and activator of transcription 3 (acute-phase response factor)
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA