Anti-TAL-1 Antibody, clone BTL73

Descrição detalhada : TAL-1, also known as SCL (stem cell leukemia), is a serine phosphoprotein and basic-helix-loop-helix transcription factor. TAL-1 is implicated in the genesis of hemopoietic malignancies and is a positive regulator of erythroid differentiation. A nonrandom, site-specific TAL-1 chromosomal translocation is commonly associated with oncogenic transformation in many T-cell acute lymphoblastic leukemias. TAL-1 binds to the LIM domain containing protein Rhombotin 2 (RBTN2), where it forms a complex with GATA1 or GATA 2 that is essential for erythropoiesis.
Sinónimos : SCL, T-cell acute lymphocytic leukemia 1, TCL5, TAL-1, Stem cell protein
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA