Anti-Tau antibody, Mouse monoclonal

Descrição detalhada : Tau is a family of microtubule-associated proteins thought to regulate the stability and organization of microtubules in neuronal cells. The tau protein family is derived from alternative mRNA splice variants that originate from a single gene, and result in mature proteins that vary in size from 352 to 441 amino acids (45 to 60 kDa). Tau loses microtubule-binding activity and aggregates into paired helical filaments (PHFs) in neurodegenerative disorders. PHFs are the basic structural components of neurofibrillary tangles (NFTs). NFT accumulation correlates with the clinical progression of Alzheimer's disease. Phosphorylation can affect the functional properties of tau and hyperphosphorylation of tau may result in the loss of tau's microtubule binding activity and the formation of the insoluble aggregates. Hyperphosphorylation and nonenzymatic glycosylation are posttranslational modifications detected in PHF-tau, and numerous sites of hyperphosphorylation of both normal and PHF-tau have been identified., Tau (?), also known as MAPT (microtubule associated protein tau), is encoded by the gene mapped to human chromosome 17q21.3. It is highly expressed in neurons, but is most prominent in axons.
Sinónimos : Anti-DDPAC; Anti-FTDP-17; Anti-MAPTL; Anti-MSTD; Anti-MTBT1; Anti-MTBT2; Anti-PPND; Anti-PPP1R103; Anti-TAU; Anti-tau-40
Armazenamento : -20C
Embalagem : 1X25UL