Anti-Tumor Necrosis Factor-alpha antibody produced in goat

Descrição detalhada : Tumor Necrosis Factor-? (TNF-?) is a cytokine produced by macrophages in response to stimulus by LPS. It plays a major role in mediating inflammation, tissue injury, pathogenic shock, innate immunity, apoptosis and autoimmunity. The physiological effects of TNF-? are mediated by receptors of TNFR super family. The TNF/TNFR signaling axis plays a critical role in mediating either survival or apoptosis depending on the class of adaptor proteins recruited in the cell. Association of receptors with a death domain causes rapid activation of caspases and results in cell death. TNF/TNFR also results in the activation of downstream pathways involving MAPK, p38, JNK and NF-?B that play a major role in innate immunity, acute inflammatory responses and homeostasis. The TNF/TNFR axis is also important in the pathology of various autoimmune and inflammatory disorders including a variety of malignancies and Alzheimer?s disease. Anti-Tumor Necrosis Factor-? antibody is specific for human TNF-?. The antibody shows less than 10% cross reactivity with recombinant rabbit TNF-? and less than 5% cross reactivity with recombinant mouse TNF-?.
Sinónimos : Anti-TNF-alpha
Armazenamento : -20C
Embalagem : 1X.1MG