Anti-Ubiquilin 2 Antibody, clone 6H9

Descrição detalhada : Ubiquilin-2, also known as Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2 (PLIC-2 or hPLIC-2), Ubiquitin-like product Chap1/Dsk2, and encoded by the gene UBQLN2/N4BP4/PLIC2, is a protein that appears to modulate the half-life of proteins destined to be degraded by the proteasome. Ubiquilin 2 binds UBE3A and BTRC ubquitin ligases and interacts with the 19S proteasome subunit to mediate its activity. Ubiquilin 2 is localized to the cytoplasm and nucleus, and colocalizes with proteasome. Ubiquilin 2 is expressed in mitotic cells very strongly; expression is low in non-dividing cells. Defects in Ubiquilin 2 may be associated with ALS form 15 a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
Sinónimos : Ubiquilin-2, Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, PLIC-2, hPLIC-2, Ubiquitin-like product Chap1/Dsk2
Armazenamento : -20°C
Embalagem : 1X1EA