Apoptosis Inhibitor – CAS 54135-60-3 – Calbiochem

Descrição detalhada : A cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml., A cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 microg/ml) and etoposide-stimulated U937 cells (IC50 = 130 microg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
Sinónimos : Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem; M50054, 2,2?-Methylenebis(1,3-cyclohexanedione)
Fórmula molecula r: C13H16O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG