Apoptosis Inhibitor II, NS3694 – CAS 426834-38-0 – Calbiochem

REF : 178494-10MG
Marca : Sigma-Aldrich
Descrição :Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
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Descrição detalhada : A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-alpha-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases., A cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-alpha-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.
Sinónimos : Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem; NS3694
Fórmula molecula r: C15H10ClF3N2O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG