Autophagy Inducer, STF-62247 – CAS 315702-99-9 – Calbiochem

REF : 189497-10MG
Marca : Sigma-Aldrich
Descrição :Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.
Clique para mais informações
Categoria :
CAS :
Descrição detalhada : A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
Sinónimos : Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem; N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
Fórmula molecula r: C15H13N3S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG