Bafilomycin A1, Streptomyces griseus – CAS 88899-55-2 – Calbiochem

REF : 196000-10UG
Marca : Sigma-Aldrich
Descrição :Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.
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Descrição detalhada : Note: 1 set = 3 x 10 µg, A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit beta-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of >=97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
Sinónimos : Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
Fórmula molecula r: C35H58O9
Armazenamento : -20C
Embalagem : 1X1EA