beta-Amyloid Oligomer Inhibitor, K01-162 – Calbiochem

Descrição detalhada : A cell permeable, fluorene compound that destabilizes the aggregation state of beta-amyloid oligomers (AbetaO) by directly targeting AbetaO and inhibiting AbetaO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AbetaO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Abeta amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
Sinónimos : beta-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem; AbetaO Inhibitor, K01-162
Fórmula molecula r: C15H14BrN
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG