beta-Catenin/Tcf Inhibitor III, iCRT3 – Calbiochem

Descrição detalhada : A cell-permeable oxazole compound that acts as a selective CRT (beta-catenin responsive transcription) inhibitor (IC50 = 8.2 nM against Wnt3a-dependent SuperTopFlash STF16-luc reporter activity in HEK293 cultures) by interfering with beta-cat-TCF4 interaction via direct beta-catenin (beta-cat) binding, while exhibiting much reduced activity against Hedgehog, Jak/Stat, or Notch signaling pathway-dependent transcription activation. Effectively inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25 to 75 µM), and selectively inhibits the proliferation of HCT116 (75 µM), HT29 (75 µM), and several primary human colon cancer cultures (6.25 to 100 µg/ml; average IC50 ~36 µg/ml) that require sustained Wnt/CRT activity for survival.
Sinónimos : beta-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem; 2-(((2-(4-Ethylphenyl)-5-methyl-1,3-oxazol-4-yl)methyl)sulfanyl)-N-(2-phenylethyl)acetamide, Inhibitor of beta-Catenin Responsive Transcription, C3, Wnt Pathway Inhibitor VIII; C3, 2-(((2-(4-Ethylphenyl)-5-methyl-1,3-oxazol-4-yl)methyl)sulfanyl)-N-(2-phenylethyl)acetamide, Inhibitor of beta-Catenin Responsive Transcription, Wnt Pathway Inhibitor VIII
Fórmula molecula r: C23H26N2O2S
Armazenamento : -20C
Embalagem : 1X10MG