Bexarotene – CAS 153559-49-0 – Calbiochem

Descrição detalhada : A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Abeta40 and Abeta42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Abeta proteases, insulin degrading enzyme, and neprilysin.
Sinónimos : Bexarotene - CAS 153559-49-0 - Calbiochem; 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
Fórmula molecula r: C24H28O2
Armazenamento : -20C
Embalagem : 1X50MG