c-Raf Inhibitor – Calbiochem

REF : 475958-20MG
Marca : Sigma-Aldrich
Descrição :c-Raf Inhibitor - Calbiochem The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
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Descrição detalhada : A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
Sinónimos : c-Raf Inhibitor - Calbiochem; 1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea, c-Raf Inhibitor
Fórmula molecula r: C23H19F3N8O
Armazenamento : 2-8C; 2-8C
Embalagem : 1X20MG