Carbonic Anhydrase IX/XII Inhibitor II, U-104 – Calbiochem

REF : 215901-5MG
Marca : Sigma-Aldrich
Descrição :Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.
Clique para mais informações
Categoria :
Descrição detalhada : A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
Sinónimos : Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem; CAIX Inhibitor II
Fórmula molecula r: C13H12FN3O3S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG