Casein Kinase I Inhibitor, D4476 – CAS 301836-43-1 – Calbiochem

Descrição detalhada : A cell-permeable triaryl substituted imidazolo compound that acts as a potent, reversible and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 0.2 µM from S. pombe; 0.3 µM for CK1delta) and ALK5 (IC50 = 0.5 µM). A weak inhibitor of p38alpha MAP kinase (IC50 = 12 µM) and only weakly affects the activities of a panel of kinases tested, including PKB, SGK and GSK-3beta. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1a in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1)., A cell-permeable, reversible, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1delta) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38alpha MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3beta. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~ 10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
Sinónimos : Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 - Calbiochem; CK1 Inhibitor, 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
Fórmula molecula r: C23H18N4O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG