Casein Kinase I Inhibitor III, PF-4800567 – Calbiochem

REF : 218719-5MG
Marca : Sigma-Aldrich
Descrição :Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIepsilon with ~22-fold greater potency over CKIdelta (IC50 = 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 µM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIepsilon cells over CKIdelta-transfected cells (IC50 = 0.13 and 2.65 µM, respectively), and PER2 degradation in COS7-GFP-PER2-CKIepsilon cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions.
Sinónimos : Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem; 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567
Fórmula molecula r: C17H18ClN5O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG