Casein Kinase II Inhibitor VIII – Calbiochem

REF : 218860-10MG
Marca : Sigma-Aldrich
Descrição :Casein Kinase II Inhibitor VIII - Calbiochem The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2alpha and CK2alpha', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
Sinónimos : Casein Kinase II Inhibitor VIII - Calbiochem; CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid
Fórmula molecula r: C18H14N2O4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG