CBFbeta Activator, Kartogenin – Calbiochem

REF : 420358-25MG
Marca : Sigma-Aldrich
Descrição :CBFbeta Activator, Kartogenin - Calbiochem The CBFbeta Activator, Kartogenin modulates the biological activity of CBFbeta. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Descrição detalhada : A cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFbeta leading to nuclear localization of CBFbeta and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
Sinónimos : CBFbeta Activator, Kartogenin - Calbiochem; 2-(Biphenyl-4-ylcarbamoyl)benzoic acid
Fórmula molecula r: C20H15NO3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG