CCR2 Antagonist – CAS 445479-97-0 – Calbiochem
REF : 227016-5MG
Marca : Sigma-Aldrich
Descrição :CCR2 Antagonist - CAS 445479-97-0 - Calbiochem The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
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Categoria : Small Molecules
Descrição detalhada : A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
Sinónimos : CCR2 Antagonist - CAS 445479-97-0 - Calbiochem; 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
Fórmula molecula r: C28H34F3N5O4S
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG
Sinónimos : CCR2 Antagonist - CAS 445479-97-0 - Calbiochem; 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
Fórmula molecula r: C28H34F3N5O4S
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG