Cdk1/2 Inhibitor III – CAS 443798-55-8 – Calbiochem

REF : 217714-1MG
Marca : Sigma-Aldrich
Descrição :Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3beta (IC50 = 140 nM), and a panel of eight other kinases (IC50 >= 1 µM).
Sinónimos : Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem; 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Fórmula molecula r: C15H13F2N7O2S2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG