Celastrol, Celastrus scandens – CAS 34157-83-0 – Calbiochem

Descrição detalhada : A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC50 = 40 nM for IL-1beta and IL-1alpha, 80 nM for IL-6, 110 nM for PGE2, and 210 nM for IL-8 and TNF-alpha), as well as LPS-induced NF-kappaB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Has also been shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Significantly improves the performance in memory, learning, and psychomotor activity in rats. May be useful to minimize inflammation in Alzheimer's disease (AD)., A cell-permeable dienone-phenolic triterpene compound with antioxidant and anti-inflammatory properties. It suppresses LPS-induced release of pro-inflammatory cytokines in macrophages and monocytes (IC50 = 40 nM for IL-1beta and IL-1alpha, 80 nM for IL-6, 110 nM for PEG2, and 210 nM for IL-8 and TNF-alpha). Also suppresses LPS-induced NF-kappaB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Improves performance in memory, learning, and psychomotor activity in rats. May be useful in minimizing inflammation in Alzheimer's disease animal models.
Sinónimos : Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem; Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
Fórmula molecula r: C29H38O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG