Clodronate, Disodium Salt – CAS 88416-50-6 – Calbiochem

Descrição detalhada : A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM)., A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
Sinónimos : Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem; Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
Fórmula molecula r: CH2Cl2Na2O6P2 · 4H2O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG