CT-2A Mouse Glioma Cell Line

Descrição detalhada : Glioblastomas are among the most aggressive forms of cancer, associated with low treatment efficacy and poor survival. Recurring glioblastomas are often resistant to first-line chemotherapies (1). There is much interest in studying drug-resistant forms of glioblastomas in the effort to develop effective therapies.References:1. Weller M, Cloughesy T, Perry JR, and Wick W (2013). Neuro Oncol 15(1): 4-27.2. Seyfried TN, el-Abbadi M, and Roy ML (1992). Mol Chem Neuropathol 17(2):147-167.3. Seyfried TN, Mukherjee P (2010). J Oncol 2010:961243 doi.10.1155/2010/961243.4. Cotterchio M, Seyfried TN (1994). J Lipid Res 35(1): 10-14. 5. Binello E, Qadeer ZA, Kothari HP, Emdad L, Germano IM (2012). J Cancer 3: 166-174.6. Martinez-Murillo R, Martinez A (2007). Histol Histopathol 22(12): 1309-1326.7. Zimmerman HM and Arnold H. (1941). Cancer Res 1(12): 919-938., The CT-2A cell line is derived from a sub-cutaneous, non-metastatic murine glioma (astrocytoma). The originating tumor was classified as poorly differentiated with high vascularity and malignancy (2). CT-2A cells are marked by high levels of complex gangliosides and low distribution of the anti-angiogenic ganglioside GM3, as well as deficiency in the tumor suppressor PTEN/TSC2, a characteristic present in up to 70% of human high-grade glioma cell lines (3,4). CT-2A tumors are wild-type for p53 and recapitulate several features of human high-grade glioma, including high mitotic index and cell density, nuclear polymorphism, hemorrhage, pseudopalisading necrosis, and microvascular proliferation (5,6). Source:CT-2A was generated from a malignant astrocytoma formed via implantation of the carcinogen 20-methylcholanthrene in the cerebrum of a C57BL/6J mouse (7). The tumor was maintained through serial intracranial transplants prior to cell line isolation.
Sinónimos : CT2A; CT2A
Armazenamento : -140C Degree Freezer
Embalagem : 1X1EA