Cytoplasmic Dynein Inhibitor, Ciliobrevin D – Calbiochem

REF : 250401-10MG
Marca : Sigma-Aldrich
Descrição :Cytoplasmic Dynein Inhibitor, Ciliobrevin D - Calbiochem Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
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Descrição detalhada : A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 µM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.
Sinónimos : Cytoplasmic Dynein Inhibitor, Ciliobrevin D - Calbiochem; 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor
Fórmula molecula r: C17H8Cl3N3O2
Armazenamento : -20C
Embalagem : 1X10MG