Deoxyhypusine Synthase Inhibitor, GC7 – CAS 150333-69-0 – Calbiochem

Descrição detalhada : A cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (Ki = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at >= 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
Sinónimos : Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem; N1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate
Fórmula molecula r: C8H22N4O4S
Armazenamento : -20C
Embalagem : 1X10MG