Dihydroorotate Dehydrogenase Inhibitor, Brequinar – CAS 96201-88-6 – Calbiochem

REF : 5083210001
Marca : Sigma-Aldrich
Descrição :Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC?? = 12 nM).
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Descrição detalhada : A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
Sinónimos : Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem; 6-fluoro-2-(2?-fluoro-1,1?-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785; NSC 368390, DuP 785, 6-fluoro-2-(2?-fluoro-1,1?-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt
Fórmula molecula r: C23H14F2NNaO2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA