DNA Base Excision Repair Pathway Inhibitor – CAS 6960-45-8 – Calbiochem

Descrição detalhada : A cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 = ~3 µM). Shown to target the APE1 active site and inhibit its 3'-phosphodiesterase and 3'-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells., A cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 ~3 µM). Shown to target the APE1 active site and inhibit its 3'-phosphodiesterase and 3'-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
Sinónimos : DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem; 7-Nitroindole-2-carboxylic acid, CRT0044876
Fórmula molecula r: C9H6N2O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG