DNA-PK Inhibitor V – CAS 404009-46-7 – Calbiochem

Descrição detalhada : A potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 0.27 µM). Inhibits the PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC50 = 32 µM, 3.7 µM, 22 µM and ~100 µM for alpha, beta, delta and gamma, respectively). Only weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI-3KC2alpha, PI-3KC2beta, PI-3KC2gamma and PI-4Kbeta, even at concentrations as high as 50 µM., A morpholino-benzophenone compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC50 = 32 µM, 3.7 µM, 22 µM and ~ 100 µM for alpha, beta, delta and gamma, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2alpha, PI 3KC2beta, PI 3KC2gamma and PI 4Kbeta, even at concentrations as high as 50 µM.
Sinónimos : DNA-PK Inhibitor V - CAS 404009-46-7 - Calbiochem; AMA37, Aryl Morpholine Analog 37, 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone
Fórmula molecula r: C17H17NO3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG