Dynamin Inhibitor I, Dynasore – CAS 304448-55-3 – Calbiochem

Descrição detalhada : A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and DeltaF508-CFTR from the plasma membrane.
Sinónimos : Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem; 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
Fórmula molecula r: C18H14N2O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG