Eg5 Inhibitor IV, VS-83 – CAS 909250-29-9 – Calbiochem

REF : 324623-5MG
Marca : Sigma-Aldrich
Descrição :Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
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Descrição detalhada : A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit >=10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
Sinónimos : Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem; 5-Fluoro-3,4-dihydro-4(3?-hydroxyphenyl)quinazoline-2(1H)-thione
Fórmula molecula r: C14H11FN2OS
Armazenamento : -20C
Embalagem : 1X5MG