EGFR Inhibitor – CAS 879127-07-8 – Calbiochem

REF : 324674-1MG
Marca : Sigma-Aldrich
Descrição :EGFR Inhibitor - CAS 879127-07-8 - Calbiochem The EGFR Inhibitor, also referenced under CAS 879127-07-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable 4,6-dianilinopyrimidine compound that acts as a potent, ATP-competitive, and highly selective inhibitor of EGFR and some EGFR mutants (IC50 = 21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively) vs. erbB4/Her4 (IC50 = 7.64 µM) and a panel of 55 other kinases. Shown to completely block EGF-induced EGFR autophosphorylation in U-2OS cells at 10 µM.
Sinónimos : EGFR Inhibitor - CAS 879127-07-8 - Calbiochem; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
Fórmula molecula r: C21H18F3N5O
Armazenamento : -20C
Embalagem : 1X1MG