Eliprodil – CAS 119431-25-3 – Calbiochem

Descrição detalhada : A negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, >100, and >100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for alpha1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain alpha receptors. Blocks neuronal voltage-gated Ca2+100, and >100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for ς1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain ς receptors. Blocks neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). A neuroprotective agent in acute ischemic stroke. Prolongs the QT interval in EKG.
Sinónimos : Eliprodil - CAS 119431-25-3 - Calbiochem; alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
Fórmula molecula r: C20H23ClFNO
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA