Erastin – CAS 571203-78-6 – Calbiochem

Descrição detalhada : A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
Sinónimos : Erastin - CAS 571203-78-6 - Calbiochem; 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
Fórmula molecula r: C30H31ClN4O4
Armazenamento : -20C
Embalagem : 1X5MG