Etoposide quinone

Descrição detalhada : Etoposide-quinone is a major metabolite of anticancer drug etoposide, which may contribute to the development of secondary acute myeloid leukemias in some etoposide patients. Etoposide-quinone is a covalent poison of human topoisomerase IIb, which induces four times more topoisomerase IIb mediated DNA cleavage than etoposide. Etoposide-quinone is a potent (IC50 = 7 muM) irreversible inhibitor of TCPTP protein tyrosine phosphatase that increases STAT1 tyrosine phosphorylation and contributes to etoposide dependent leukemogenesis.
Sinónimos : Etoposide 3',4'-quinone; Etoposide o-quinone
Fórmula molecula r: C28H28O13
Armazenamento : -20C
Embalagem : 1X250MG