FABP4 Inhibitor – CAS 300657-03-8 – Calbiochem

Descrição detalhada : A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = <2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
Sinónimos : FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem; adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2?-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1?-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
Fórmula molecula r: C31H26N2O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG