Fas/FasL Antagonist, Kp7-6 – Calbiochem

Descrição detalhada : An exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-alpha or TNFR., An exocyclic cystine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling pathways. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-alpha or TNFR.
Sinónimos : Fas/FasL Antagonist, Kp7-6 - Calbiochem; H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6
Fórmula molecula r: C48H56N10O15S2
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG