Fluoxetine, Hydrochloride – CAS 56296-78-7 – Calbiochem

Descrição detalhada : A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB., A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca2+ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K+ currents in a reversible and voltage-independent manner (IC50 = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.
Sinónimos : Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem; dl-N-Methyl-3-( p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro- p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
Fórmula molecula r: C17H18F3NO
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG