Fmoc-thioproline

Descrição detalhada : A building block for the intoduction of thiaproline (Thz) during Fmoc SPPS. Thz has been employed as a masked cysteine residue to prevent self-ligation during native chemical ligation reactions (NCL) of peptide thioesters bearing an N-terminal Cys residue [6]. Once ligation is complete, the N-terminal Cys residue of the resultant peptide is unmasked by ring opening the Thz residue by treatment with methoxyamine, thereby enabling its subsequent ligation to another peptide thioester fragment.
Sinónimos : Fmoc-thioproline; Fmoc-thiaproline,Fmoc-thiazolidine-4-carboxylic acid
Fórmula molecula r: C19H17N4S
Armazenamento : 15-25C
Embalagem : 1X1EA