Furin Inhibitor I – Calbiochem

Descrição detalhada : A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (beta-site APP-cleaving enzyme)., A peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (beta-site APP-cleaving enzyme).
Sinónimos : Furin Inhibitor I - Calbiochem; Decanoyl-RVKR-CMK
Fórmula molecula r: C34H66ClN11O5
Armazenamento : -20C
Embalagem : 1X1MG