gamma-Secretase Inhibitor XII – Calbiochem

Descrição detalhada : A cell-permeable, reversible dipeptide aldehyde that reduces amyloid-beta protein (Abeta) production by blocking gamma-secretase activity in vitro (Abeta40 IC50 = 7.9 µM; Abeta42 IC50 = 7.6 µM) and in cultured cells that stably over-express APP695 (Abeta40 IC50 = 11.5 µM; Abeta42 IC50 = 8.3 µM). Also shown to block the generation of gammaCTF (gamma-secretase-generated carboxy-terminal fragment)., A cell-permeable, reversible dipeptide aldehyde that reduces Abeta production by blocking gamma-secretase activity in vitro (Abeta40 IC50 = 7.9 µM; Abeta42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Abeta40 IC50 = 11.5 µM; Abeta42 IC50 = 8.3 µM). Also blocks the generation of CTFgamma (gamma-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-beta-precursor protein (APP).
Sinónimos : gamma-Secretase Inhibitor XII - Calbiochem; Z-IL-CHO
Fórmula molecula r: C20H30N2O4
Armazenamento : -20C
Embalagem : 1X5MG