gamma-Secretase Inhibitor XX – CAS 209984-56-5 – Calbiochem

Descrição detalhada : A cell-permeable, potent gamma-secretase inhibitor that significantly lowers both brain and plasma Abeta40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p)., A cell-permeable dibenzazepine (dbz) compound that acts as a potent gamma-secretase inhibitor and significantly lowers both brain and plasma Abeta40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p).
Sinónimos : gamma-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem; (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
Fórmula molecula r: C26H23F2N3O3
Armazenamento : -20C
Embalagem : 1X500UG