GluN2B NMDA Receptor Antagonist, 93-31 – Calbiochem

Descrição detalhada : A tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 <= 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
Sinónimos : GluN2B NMDA Receptor Antagonist, 93-31 - Calbiochem; (S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
Fórmula molecula r: C22H30Cl2N2O4S
Armazenamento : -20C
Embalagem : 1X1EA