Goe 6976 – CAS 136194-77-9 – Calbiochem

Descrição detalhada : A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC alpha-isozyme (IC50 = 2.3 nM) and PKCbetaI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC delta-, epsilon-, and zeta-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Goe 6976 (Cat. No. 365253) in anhydrous DMSO is also available., A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCalpha-isozyme (IC50 = 2.3 nM) and PKCbetaI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC delta-, epsilon-, and zeta-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
Sinónimos : Goe 6976 - CAS 136194-77-9 - Calbiochem; Go 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
Fórmula molecula r: C24H18N4O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X500UG