GR 127935 Hydrochloride – CAS 148642-42-6 – Calbiochem

Descrição detalhada : A selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
Sinónimos : GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem; 5-HT 1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride
Fórmula molecula r: C29H31N5O3 · xHCl
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA