GSK-3beta Inhibitor I – CAS 327036-89-5 – Calbiochem

REF : 361540-5MG
Marca : Sigma-Aldrich
Descrição :GSK-3beta Inhibitor I - CAS 327036-89-5 - Calbiochem The GSK-3beta Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3beta. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3beta (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 µM). Shown to inhibit collagen- and thrombin-induced platelet aggregation., A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3beta (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 >100 µM). Binds to the active site of GSK-3beta.
Sinónimos : GSK-3beta Inhibitor I - CAS 327036-89-5 - Calbiochem; TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Fórmula molecula r: C10H10N2O2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG